Microvesicles and Prostate Cancer: Biomarkers and Release Mechanisms
Group information, relevant EV research and instrumentation |
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Group name |
Microvesicles and Prostate Cancer: Biomarkers and Release Mechanisms |
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Affiliation |
Institute for Cancer Research, Dept. of Molecular Cell Biology, Oslo University Hospital, The Norwegian Radium Hospital
Link to homepage: http://www.ous-research.no/llorente/
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Name |
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Phone |
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Steering group member |
Alicia Llorente Senior scientist |
90892782 |
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Deputy representative |
Tore Skotland Senior scientist |
22781933 |
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Group members |
Kirsten Sandvig Professor |
22781828 |
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Nina P. Hessvik Postdoc |
22781824 |
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Ivana Malovic Postdoc |
22781802 |
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Dhaksshaginy Rajalingam Master Student |
22781803 |
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Cristina Bajo Guest PhD student |
22781825 |
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Scientific background/relevant EV research The principal objective of the project is to obtain new knowledge about EVs that can help us to better understand and diagnose pathological conditions. To reach this objective the following subprojects are being developed: 1. Biogenesis and release of exosomes. We aim at identifying the molecules that regulate the biogenesis and release of exosomes. In particular, we are studying the role of lipids and of lipid-associated proteins in this process. Lipids are known to be involved in vesicular transport and could affect the secretion of exosomes by inducing curvature stress or by altering signaling pathways. We approach the problem by using pharmacological compounds and siRNA to inhibit enzymes involved in lipid synthesis. 2. Identification of prostate cancer biomarkers in exosomes. Extracellular vesicles contain a variety of molecules and have recently emerged as a novel source of biomarkers. We have previously identified the proteomic, lipidomic and microRNA profile of exosomes released by the prostate cancer line PC-3. We are now investigating the use of some interesting candidates in biological samples.
External collaborators: Kim Ekroos, Zora Biosciences, Finland, contributes to the project with his experience in lipid biology and lipidomics. Viktor Berge, Department of Urology, Oslo University Hospital-Aker, Norway, contributes to the project with his experience in prostate cancer clinical research. Andreas Brech, Institute for Cancer Research-The Norwegian Radium Hospital, Oslo University Hospital, Norway, contributes to the project with his experience in electron microscopy. Bernd Thiede, Faculty of Mathematics and Natural Sciences, University of Oslo, Norway, contributes to the project with his experience in proteomics. Aija Line, Latvian Biomedical Research and Study Centre, Latvia, contributes to the project with his experience in EVs and cancer.
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Instrumentation (relevant for EV research):
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Date |
August 25th, 2015 |